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#antiinflammatory

2 posts2 participants0 posts today
Public
Ms. Que Banh

Don't toss/compost your homegrown #PepperLeaves. #Harvest them because they're food. They can be used as herbs substitute if you don't have basil or mints. They can be cooked & eaten. They're nutritious, so start eating your pepper leaves!

Mom had told me that in her matriarch village, our relations grew & harvested #peppers & #leaves for many generations. It's used in many different Asian cultures as both food & medicine.

Pepper leaves #HealthBenefits ⬇️

#Antioxidants -
Pepper leaves are rich in antioxidants, which help protect the body from damage caused by free radicals.

#AntiInflammatory -
Pepper leaves have anti-inflammatory properties that help reduce inflammation in the body.

#DigestiveHealth -
Pepper leaves can aid in digestion and reduce stomach upset.

#ImmunityBoost -
Pepper leaves contain vitamins and minerals that help boost the immune system

I used these harvested pepper leaves to fry up with garlic & eggs for my Mom 😊 It's #DiabeticFriendly 👍

A white plastic colander with green pepper leaves harvested from chili plant.
#AsianMastodon#EatLeaves#SouthEastAsianFood
Public
Broadwaybabyto

I’ve seen a number of people debating giving up dairy as concerns over avian flu grow. I gave it up nearly 20 years ago in an attempt to help with inflammation - and when I was healthier I experimented with making my own nut cheeses & milks. I wanted to share some basic ideas & inspiration for anyone considering going plant based.

The first photo is banana “nice cream”… an excellent & healthy substitute for ice cream. Freeze ripe bananas and place them in a high speed blender with sweetener of choice (I used dates), other fruit, chocolate, cinnamon… the possibilities are endless & the texture on point.

You can also use frozen bananas to make smoothie bowls! This one was high protein & full of vitamins & minerals. Dark cherries, cacao powder, hemp seeds, chia seeds & walnuts blended with cashew milk, dates, cinnamon & pink salt. Could easily be an entire meal

For a tropical feel you can top your chocolate nice cream with a mango sorbet! Frozen mangos blended with water & figs which add extra sweetness! 1/4

Photo of a smoothie bowl that’s dark cherry and topped with chocolate - ripe bananas are pictured in a bunch above the bowl
Photo of a cherry coloured smoothie bowl inside a coconut husk dish. It’s topped with hemp seeds, walnuts and rolled oats.
Mason jar with cherry banana ice cream on the bottom and mango fig sorbet on top. Sliced figs garnish the rim.
#ChronicIllness#Disability#LongCovid
Public
lobster 🦞

Dear Friends on Socialism Media, 🕊️

As we pay for UBI bye:
Defunding Pilionaires, D-Elites, Aristos, Ms Informers, The Right Entitled etc.

We Find/fund:
- Room for Life
- Free to Bee
- Honeys ❤️
- All manner of civil
- A Way ✔️
- Africa

Meanwhile ... personally, I connected with Matrix and IRC. Starting to GNU/You (who knew?). Learning new ways to be on the Interweb. Can now #cope with greater degrees of sanity. For example, drinking #chamomile. #Turmeric and #pepper coffee (#anti-inflammatory). As an Ancient Smith (#Alchemist) I may appear as #Matrix A gent or #dissimilation Borg. Do not be fooled, that is my #superpower ...

Stay #detuned, #feisty #fiesta and on your tows. We have our backs up.

www.freecycle.org/

www.freecycle.orgFreecycle: Front Door
#antiinflammatory
Public
DoomsdaysCW

#Cannabinoids as novel #AntiInflammatory drugs

by Prakash Nagarkatti, et al.
October, 2009

Abstract:

"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."

Executive summary

- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.

ncbi.nlm.nih.gov/pmc/articles/

PubMed Central (PMC)Cannabinoids as novel anti-inflammatory drugsCannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ[9] -tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors ...
Public
DoomsdaysCW

#Cannabidiol (#CBD): a killer for #inflammatory rheumatoid #arthritis synovial fibroblasts

Published: 01 September 2020
by Torsten Lowin, et al.

Abstract:

"Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions."

Source:
nature.com/articles/s41419-020

NatureCannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts - Cell Death & DiseaseCannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions.
#Cannabis#AntiInflammatory
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