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#q

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Rxiv mechanobio

📰 "Modular integration of neural connectomics, dynamics and biomechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans"
arxiv.org/abs/2504.18073 #Extra-Cellular #Mechanical #Q-Bio.Qm #Dynamics #Q-Bio.Nc

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arXiv.orgModular integration of neural connectomics, dynamics and biomechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegansComputational approaches which emulate in-vivo nervous system are needed to investigate mechanisms of the brain to orchestrate behavior. Such approaches must integrate a series of biophysical models encompassing the nervous system, muscles, biomechanics to allow observing the system in its entirety while supporting model variations. Here we develop modWorm: a modular modeling framework for the nematode C. elegans. modWorm allows for construction of a model as an integrated series of configurable, exchangeable modules each describing specific biophysical processes across different modalities. Utilizing modWorm, we propose a base neuro-mechanical model for C. elegans built upon the complete connectome. The model integrates a series of 7 modules: i) intra-cellular dynamics, ii) electrical and iii) chemical extra-cellular neural dynamics, iv) translation of neural activity to muscle calcium dynamics, v) muscle calcium dynamics to muscle forces, vi) muscle forces to body postures and vii) proprioceptive feedback. We validate the base model by in-silico injection of constant currents into neurons known to be associated with locomotion behaviors and by applying external forces to the body. Applications of in-silico neural stimuli experimentally known to modulate locomotion show that the model can recapitulate natural behavioral responses such as forward and backward locomotion as well as mid-locomotion responses such as avoidance and turns. Furthermore, through in-silico ablation surveys, the model can infer novel neural circuits involved in sensorimotor behaviors. To further dissect mechanisms of locomotion, we utilize modWorm to introduce empirical based model variations and model optimizations to elucidate their effects on simulated locomotion. Our results show that modWorm can be utilized to identify neural circuits which control, mediate and generate natural behavior.
Public
Alo Japan

alojapan.com/1257896/a-photogr A photographer wants to document Japan’s arcades before it’s too late #books #culture #gaming #Japan #JapanNews #news #q&a Depending who you ask, arcades have been dead or dying or on their last legs for… almost 40 years now. The reality is more complex, with new business models, barcades, bigger complexes like Dave & Busters, and VR/immersive/experimental options taking their place. But the classic arcade, where you could drop a couple q…

A photographer wants to document Japan’s arcades before it’s too late
Public
Vladimir Savić

"My impression is #AI gives you the consensus or most common answer or solution. It really doesn't handle multi constraint problems well at all. Really never saw any unique, new or creative engineering solutions, which in my book is a true sign of intelligence." #q

Public
Rxiv mechanobio

📰 "Functional Amyloid Fibrils as Versatile Tools for Novel Biomaterials"
arxiv.org/abs/2504.15532 #Mechanical #Q-Bio.Bm #Cell

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arXiv.orgFunctional Amyloid Fibrils as Versatile Tools for Novel BiomaterialsFunctional amyloid fibrils, once primarily associated with amyloidosis, are now recognized for their exceptional potential as biomaterials due to their unique structural features, including remarkable mechanical strength, high stability, and self-assembly capabilities. This review highlights their transformative applications across a wide range of industries, from cutting-edge drug delivery systems and next-generation biosensors to tissue engineering, surface technologies, energy storage, and environmental solutions. Their versatility extends into innovative sectors like information transfer systems, cell adhesion, protein fusion, food technology, and novel catalytic systems. Despite significant progress, critical gaps remain in the research. This review not only consolidates current applications but also underscores the vast potential for future advancements, positioning functional amyloids as key players in emerging biomaterials technologies.
Public
Rxiv mechanobio

📰 "Biomechanics of orientationally ordered epithelial tissue"
arxiv.org/abs/2504.10689 #Cond-Mat.Soft #Cytoskeletal #Mechanical #Q-Bio.To

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arXiv.orgBiomechanics of orientationally ordered epithelial tissueOrganogenesis involves large deformations and complex shape changes that require elaborate mechanical regulation. Models of tissue biomechanics have been introduced to account for the coupling between mechanical response and biochemical processes. Recent experimental evidence indicates that the mechanical response of epithelial tissue is strongly anisotropic, with the degree of anisotropy being correlated with the existence of long range orientational order of cytoskeletal organization across the tissue. A theoretical framework is introduced that captures the dynamic feedback between tissue elastic response and cytoskeletal reorganization under stress. Within the linear regime for small and uniform applied strains, the shear modulus is effectively reduced by the nematic order in cytoskeletal alignment induced by the applied strain. This prediction agrees with experimental observations of epithelial response in lithographically patterned micro tissues.
Public
Rxiv mechanobio

📰 "The role of hydrodynamics in the synchronisation of {\it Chlamydomonas} flagella"
arxiv.org/abs/2504.02680 #Physics.Bio-Ph #Mechanical #Q-Bio.Cb #Cell

arXiv.orgThe role of hydrodynamics in the synchronisation of {\it Chlamydomonas} flagellaWhile hydrodynamic coupling has long been considered essential for synchronisation of eukaryotic flagella, recent experiments on the unicellular biflagellate model organism {\it Chlamydomonas} demonstrate that -- at the single cell level -- intracellular mechanical coupling is necessary for coordination. It is therefore unclear what role, if any, hydrodynamic forces actually play in the synchronisation of multiple flagella within individual cells, arguably the building block of large scale coordination. Here we address this question experimentally by transiently blocking hydrodynamic coupling between the two flagella of single {\it Chlamydomonas}. Our results reveal that in wild type cells intracellularly-mediated forces are necessary and sufficient for flagellar synchronisation, with hydrodynamic coupling causing minimal changes in flagellar dynamics. However, fluid-mediated ciliary coupling is responsible for the extended periods of anti-phase synchronisation observed in a mutant with weaker intracellular coupling. At the single-cell level, therefore, flagellar coordination depends on a subtle balance between intracellular and extracellular forces.
Public
Rxiv mechanobio

📰 "Intercellular contact is sufficient to drive Fibroblast to Myofibroblast transitions"
arxiv.org/abs/2503.01834 #Extracellular #Mechanical #Q-Bio.Cb

arXiv.orgIntercellular contact is sufficient to drive Fibroblast to Myofibroblast transitionsFibroblast cells play a key role in maintaining the extracellular matrix. During wound healing, fibroblasts differentiate into highly contractile myofibroblasts, which secrete extracellular matrix proteins like collagen to facilitate tissue repair. Under normal conditions, myofibroblasts undergo programmed cell death after healing to prevent excessive scar formation. However, in diseases like fibrosis, the myofibroblasts remain active even after the wound is closed, resulting in excessive collagen buildup and a stiff, fibrotic matrix. The reasons for the persistence of myofibroblasts in fibrosis are not well understood. Here we show the existence of a mechanism where direct physical contact between a fibroblast and a myofibroblast is sufficient for fibroblasts to transition into myofibroblasts. We show that fibroblast-myofibroblast transition can occur even in the absence of known biochemical cues such as growth factor activation or mechanical cues from a stiff, fibrotic matrix. Further, we show that contact-based fibroblast-myofibroblast activation can be blocked by Gαq/11/14 inhibitor FR9003591, which inhibits the formation of myofibroblasts. These findings offer new insights into the persistence of fibrosis despite therapeutic interventions and suggest a potential strategy to target fibroblast-to-myofibroblast transition in fibrosis.
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Jonathan Emmesedi

@Erzbet

Thank you as always for setting this up and choosing a fun theme; you make every Monday fun!

I have not played any video games since staying up into the small hours playing Space Invaders decades ago, so I am not well informed about video gaming in more recent years.

Nevertheless I think I'm right in saying that the video gaming shown in Cherry Bullet's six year old "Q & A" was very retro even then, and must look positively paleo to younger gamers now. It's all part of the delight that the makers of Kpop MVs show in incorporating older technologies such as landline telephones or cathode ray television sets into videos.

I like "Q & A", and I think it's a shame that Cherry Bullet and their bright bubblegum pop were not more successful. Thank goodness that YouTube and the internet in general continue to give us access to these treasures of pop culture past; I worry that some point YouTube/ Alphabet /Capitalism is going to say "Game Over -- Insert More Coins To Continue".

#Kpop #KpopMonday #VideoGame #CherryBullet #Q&A #GirlGroups

youtu.be/5LCGn9UFNAY?si=_R4CKX

YouTube[MV] 체리블렛(Cherry Bullet) _ Q&ABy 1theK (원더케이)
Public
The Propaganda Site

Soul, funk, and pop come together seamlessly in Q's sweet and tuneful songs that are coupled with his smooth voice and strong, nuanced delivery.

Find out more about his music at thepropagandasite.com/artist/q

the PROPAGANDA siteQ | the PROPAGANDA siteQ Marsden (who goes by first name alone) is a singer, songwriter from Browder County, Florida, who currently plays retro soul with pop and funk connections. He roams the pop and soul world of the '80s, drawing inspiration from artists like Quincy Jones, Michael Jackson, and Prince all at their funkiest peaks. And he achieves this effect not only as a matter of arrangement and delivery, but also by somehow channelling the way the melodies feel. His previous work, on the other hand, was mostly in the alternative R&B universe with an obvious affection for lounge jazz, a low-key occasional Latin-flavored acoustic guitar, and dream pop tones lurking underneath the surface. He moved away from that on 2023's Soul, PRESENT, fully embracing a classic pop oriented soul sound complete with a lovely falsetto.
#music#musicdiscovery#tPsThrowback
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